1
: either of two retroviruses (Lentivirus humimdef1 and L. humimdef2) that infect and destroy helper T cells of the immune system and that when left untreated cause AIDS

Note: HIV retroviruses are transmitted through contact with blood, semen, rectal and vaginal fluids, or breast milk and typically cause flu-like symptoms during the acute phase of infection, but often cause few or no symptoms during the chronic phase of infection when treated with antiretroviral drugs.

… the longer people are infected with HIV and the more immune-deficient they become, the more readily they seem to pass HIV to others.Robert R. Redfield et al.
Years of careful research have proven beyond doubt that the HIV virus causes AIDS, that antiretroviral drug treatment saves lives, and that the drug nevirapine is safe and effective in preventing the spread of HIV from mothers to their babies.Richard Marlink et al.

called also AIDS virus, human immunodeficiency virus

see also hiv-1, hiv-2
2
: the infection or disease caused by HIV
Early symptoms of HIV develop in 50 to 90 percent of people who are infected, usually beginning two to four weeks after exposure. … Because the signs and symptoms of … HIV may be similar to other common illnesses, such as mononucleosis, most people do not initially realize that they have HIV.Paul E. Sax

Examples of HIV in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
People may also be experiencing housing insecurity, poverty, trauma, mental illness, HIV, or other chronic conditions. Joel Teron, New York Daily News, 31 Aug. 2026 The tablet combines bictegravir, the backbone of Gilead’s blockbuster HIV pill Biktarvy, with lenacapavir, a first-in-class capsid inhibitor that has become a centerpiece of the company’s long-term strategy for HIV treatment and prevention. Justina Lee, CNBC, 28 Aug. 2026 The organization focuses on working with groups who have been impacted by HIV/AIDS and provides treatment, prevention and supporting resources. Alexandra Schonfeld, PEOPLE, 26 Aug. 2026 Additionally, pregnant women who are at a heightened risk of contracting HIV should be tested at the beginning of their pregnancy and again during the third trimester, says the CDC. Tj Rhodes, Sioux Falls Argus Leader, 26 Aug. 2026 See All Example Sentences for HIV

Word History

First Known Use

1986, in the meaning defined at sense 1

Time Traveler
The first known use of HIV was in 1986

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Cite this Entry

“HIV.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/HIV. Accessed 1 Sep. 2026.

Kids Definition

: any of a group of viruses that infect and destroy helper T cells causing the marked reduction in their numbers that is diagnostic of AIDS

Medical Definition

1
: either of two retroviruses (Lentivirus humimdef1 and L. humimdef2) that infect and destroy helper T cells of the immune system and that when left untreated cause AIDS

Note: HIV retroviruses are transmitted through contact with blood, semen, rectal and vaginal fluids, or breast milk and typically cause flu-like symptoms during the acute phase of infection, but often cause few or no symptoms during the chronic phase of infection when treated with antiretroviral drugs.

called also AIDS virus, human immunodeficiency virus

see also hiv-1, hiv-2
2
: the infection or disease caused by HIV
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