: of, relating to, or common to a system: such as
a
: affecting the body generally
systemic diseases
b
: supplying those parts of the body that receive blood through the aorta rather than through the pulmonary artery
c
: of, relating to, or being a pesticide that as used is harmless to the plant or higher animal but when absorbed into its sap or bloodstream makes the entire organism toxic to pests (such as an insect or fungus)
There's also the issue of pollinator health. Once a systemic pesticide is applied it travels through the entire tree and pollinators can take it up.Dave Shaw, quoted in The Oregonian (Portland, Oregon)
d
: fundamental to a predominant social, economic, or political practice
… the systemic poverty instigated and perpetuated by … punitive government policy.Stephanie Convery
People are tired of marching. People are tired of hashtag protests. People want some systemic change.Rev. Tiffany Thomas
see also systemic racism
Systematic and Systemic: Usage Guide

Systematic and systemic both come from system. Systematic is the more common word; it most often describes something that is done according to a system or method.

a systematic approach to learning that involves carefully following the program's steps

Systemic describes what relates to or affects an entire system, be that system physical, organizational, or societal. For example, a systemic disease affects the entire body or organism, and systemic changes to an organization have an impact on the entire organization, including its most basic operations. Systemic is also used specifically to identify something as fundamental to a predominant social, economic, or political practice.

systemic racism

systemic

2 of 2

noun

: a systemic pesticide

Examples of systemic in a Sentence

Adjective The company made some systemic changes to the way it operated. The problem seems to be systemic.
Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Adjective
Khan said that studies have shown GLP-1s and dual GIP/GLP-1 medications decrease cardiovascular risk by lowering blood pressure, reducing systemic inflammation and improve blood lipid profiles alongside weight loss. Mary Kekatos, ABC News, 29 Aug. 2026 New York utilities’ own transmission projects reveal the systemic challenge. Joshua MacEy, Hartford Courant, 28 Aug. 2026 For Smotkin, the water crisis reflects the island’s history of structural neglect and systemic abandonment by both local and federal authorities. Isabel Rosales, CNN Money, 28 Aug. 2026 Multiply that error across an entire directory, and a data quality problem becomes a systemic trust issue. Morgan Beschle, Forbes.com, 28 Aug. 2026 See All Example Sentences for systemic

Word History

First Known Use

Adjective

1803, in the meaning defined above

Noun

1951, in the meaning defined above

Time Traveler
The first known use of systemic was in 1803

Browse Nearby Words

Cite this Entry

“Systemic.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/systemic. Accessed 1 Sep. 2026.

Kids Definition

systemic

adjective
sys·​tem·​ic
sis-ˈtem-ik
: of, relating to, or common to a system: as
a
: of or relating to the body as a whole
a systemic disease
b
: concerned with the circulation that supplies blood to the bodily tissues through the aorta rather than the circulation involved in carrying blood through the pulmonary artery
c
: fundamental to a predominant social, economic, or political practice
systemic change

Medical Definition

systemic

1 of 2 adjective
: of, relating to, or common to a system: as
a
: affecting the body generally compare local
b
: supplying those parts of the body that receive blood through the aorta rather than through the pulmonary artery
c
: being a pesticide that as used is harmless to a higher animal or a plant but when absorbed into the bloodstream or the sap makes the whole organism toxic to pests (as cattle grubs, mites, or aphids)

systemic

2 of 2 noun
: a systemic pesticide
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