1
: not opposed
an unopposed invasion
: having no opponent
a politician who is running for election unopposed
2
medical : being or relating to estrogen replacement therapy in which a progestin (such as medroxyprogesterone acetate) is not coadministered to reduce the potential risks (such as endometrial cancer) associated with estrogen used alone
A woman who has had her uterus removed can take the estrogen "unopposed"—that is, without the addition of progestin.Consumer Reports

Examples of unopposed in a Sentence

Recent Examples on the Web
Examples are automatically compiled from online sources to show current usage. Read More Opinions expressed in the examples do not represent those of Merriam-Webster or its editors. Send us feedback.
Clark won a solid 56% of the vote in the Democratic primary, beating Blair and others, and Chavez ran unopposed in the Republican primary. Irene Wright, USA Today, 25 Aug. 2026 Chavez, who ran unopposed for the GOP nomination, challenged David Scott in the 2024 general election and received about 28% of the vote. CBS News, 24 Aug. 2026 Parks ran unopposed in 2014 and defeated fellow Republican Tad Schnaufer in 2018 with 72% of the vote. James Wilkins, The Orlando Sentinel, 19 Aug. 2026 The Rancho Cordova City Council decided to put an unopposed candidate before voters rather than appoint him to the 2nd District seat, a decision expected to cost the city more than $14,000. Camryn Dadey, Sacbee.com, 18 Aug. 2026 See All Example Sentences for unopposed

Word History

First Known Use

1625, in the meaning defined at sense 1

Time Traveler
The first known use of unopposed was in 1625

Browse Nearby Words

Cite this Entry

“Unopposed.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/unopposed. Accessed 1 Sep. 2026.

Medical Definition

unopposed

adjective
: being or relating to estrogen replacement therapy in which a progestin (as medroxyprogesterone acetate) is not coadministered to reduce the potential risks (as endometrial cancer) associated with estrogen used alone
Love words? Need even more definitions?

Subscribe to America's largest dictionary and get thousands more definitions and advanced search—ad free!