plural ceramides
: any of various simple sphingolipids that are composed of a fatty acid linked to sphingosine, are found especially in cell membranes, are involved in mediating various cellular processes (such as those affecting cell differentiation and apoptosis), and act as precursors for more complex sphingolipids
The enzyme controls production of a cellular substance, ceramide, which triggers the natural process of egg cell death.L. Stivitz
Moisturizers containing ceramides (natural lipids that are similar in structure to those in the skin's own moisture barrier) … are also worthwhile splurges for women with dry or problem skin, according to independent tester Grove.Constance Cardozo

Examples of ceramide in a Sentence

Recent Examples on the Web
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Moisturizing Cream, which carries the National Eczema Association’s Seal of Acceptance, contains three different types of ceramides to soothe dry skin and help rebuild its protective barrier. Ayren Jackson-Cannady, Allure, 1 Sep. 2026 Hyaluronic acid hydrates your skin, while ceramides replenish the skin barrier. Maggie Ryan, Flow Space, 1 Sep. 2026 It is best used as part of a nourishing multi-step skincare routine that includes a ceramide-rich moisturiser, but more on that below. Ellie Davis, Vogue, 28 Aug. 2026 Hyaluronic acid and ceramides hydrate and strengthen the skin barrier. Casey Delbasso, ABC News, 24 Aug. 2026 See All Example Sentences for ceramide

Word History

Etymology

cerebroside + amide

First Known Use

1958, in the meaning defined above

Time Traveler
The first known use of ceramide was in 1958

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Cite this Entry

“Ceramide.” Merriam-Webster.com Dictionary, Merriam-Webster, https://www.merriam-webster.com/dictionary/ceramide. Accessed 2 Sep. 2026.

Medical Definition

: any of various simple sphingolipids that are composed of a fatty acid linked to sphingosine, are found especially in cell membranes, are involved in mediating various cellular processes (such as those affecting cell differentiation and apoptosis), and act as precursors for more complex sphingolipids
Elevated plasma levels of many of the sphingolipids have also been correlated with chronic disease—for example, sphingomyelins with coronary heart disease and ceramides with type 2 diabetes and Alzheimer's disease.Oswald Quehenberger and Edward A. Dennis, The New England Journal of Medicine

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